Hyperthermia by near infrared radiation induced immune cells activation and infiltration in breast tumor

Abstract Breast cancer is the most common that causes death in women. Conventional therapies, including surgery and chemotherapy, have different therapeutic effects are commonly associated with risks side effects. Near infrared radiation a technique few used for local hyperthermia, typically as an adjuvant to other therapies. The understanding of use near NIR monotherapy, its on immune cells activation infiltration, limited. In this study, we investigate HT treatment using tumor regression molecules breast tumors. Results from study demonstrated by at 43 °C reduced progression significantly increased median survival tumor-bearing mice. Immunohistochemical analysis revealed significant reduction proliferation treated tumor, which was accompanied abundance heat shock protein 70 (Hsp70). Increased numbers activated dendritic were observed draining lymph nodes mice, along infiltration T cells, NK B into tumor. contrast, tumor-infiltrated regulatory largely diminished addition, higher IFN-γ IL-2 secretion Overall, results present extends stimulate favourable response against cancer.